During aggnephagy the cargo is composed of aggregated proteins (in blue). They look like a tangle of threads like in this illustration, as they are mulfunctioning. In higher eukaryotes (e.i. humans) aggregated cargo is tagged with a label molecule named ubiquitin ( ubiquitously expressed in the body) here in orange. In turn, when the cargo receptor p62 (violet threads) sticks to ubiquitin it leads the formation of an autophagosome (yellow membrane vesicle) around it to ensure pick up. This illustration was created for this article.
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